THZ2

Izina ryimiti:

N- [3 - [[5-chloro-4- (1H-indol-3-yl) pyrimidin-2-yl] amino] fenyl] -3 - [ enoyl] amino] benzamide

Kode ya SMILES:

O = C (NC1 = CC = CC (NC2 = NC = C (Cl) C (C3 = CNC4 = C3C = CC = C4) = N2) = C1) C5 = CC = CC (NC (/ C = C / CN) (C) C) = O) = C5

InChi Code:

InChI = 1S / C31H28ClN7O2 / c1-39 (2) 15-7-14-28 (40) 35-21-9-5-8-20 (16-21) 30 (41) 36-22-10-6- 11-23 (17-22) 37-31-34-19-26 (32) 29 (38-31) 25-18-33-27-13-4-3-12-24 (25) 27 / h3-14,16-19,33H, 15H2,1-2H3, (H, 35,40) (H, 36,41) (H, 34,37,38) / b14-7 +

InChi Urufunguzo:

FONRCZUZCHXWBD-VGOFMYFVSA-N

Ijambo ryibanze:

THZ-2, THZ 2, THZ2, 1604810-84-5

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

THZ2, igereranya na THZ1, ifite ubushobozi bwo kuvura kanseri y'ibere ya gatatu-mbi (TNBC), ni inhibitor ikomeye kandi itoranya CDK7 inesha ihungabana rya THZ1 muri vivo. IC50: CDK7 = 13.9 nM; TNBC selile = 10 nM

Intego: CDK