SEL120-34A

Izina ryimiti:

7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo [4,5,1-ij] quinoline Hydrochloride

Kode ya SMILES:

CC1 = C (Br) C (Br) = C2CCCN3C2 = C1N = C3N4CCNCC4. [H] Cl

InChi Code:

InChI = 1S / C15H18Br2N4.ClH / c1-9-11 (16) 12 (17) 10-3-2-6-21-14 (10) 13 (9) 19-15 (21) 20-7-4- 18-5-8-20; / h18H, 2-8H2,1H3; 1H

InChi Urufunguzo:

GQXLWUCQESKBSC-UHFFFAOYSA-N

Ijambo ryibanze:

SEL120-34A; SEL 120-34A; SEL-120-34A; SEL12034A; SEL 12034A; SEL-12034A

Gukemura: 

Ububiko: 

Ibisobanuro:

SEL120-34A ninzitizi ikomeye kandi yatoranijwe ya CDK8 ikora muri selile ya AML ifite urwego rwo hejuru rwa fosifora ya serine ya STAT1 na STAT5 transactivation. EL120-34A ibuza fosifora ya STAT1 S727 na STAT5 S726 muri selile ya kanseri muri vitro. Mubisanzwe, amabwiriza ya STATs- na NUP98-HOXA9- kwandukura byaragaragaye nkuburyo bwiganje bwibikorwa muri vivo.

Intego: CDK8