MSC2530818

Izina ryimiti:

[(2S) -2- (4-Chlorophenyl) pyrrolidin-1-yl] - (3-methyl-1H-pyrazolo [3,4-b] pyridin-5-yl) methanone

Kode ya SMILES:

O = C (N1 [C @ H] (C2 = CC = C (Cl) C = C2) CCC1) C3 = CN = C (NN = C4C) C4 = C3

InChi Code:

InChI = 1S / C18H17ClN4O / c1-11-15-9-13 (10-20-17 (15) 22-21-11) 18 (24) 23-8-2-3-16 (23) 12-4- 6-14 (19) 7-5-12 / h4-7,9-10,16H, 2-3,8H2,1H3, (H, 20,21,22) / t16- / m0 / s1

InChi Urufunguzo:

ODRITQGYYWHQGM-INIZCTEOSA-N

Ijambo ryibanze:

MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

MSC2530818 ni Imbaraga, Guhitamo, no Muburyo Bioavailable CDK8 Inhibitor hamwe na CDK8 IC50 = 2.6 nM; Ubuhanuzi bwa muntu PK: Cl ~ 0.14 L / H / Kg; t1 / 2 ~ 2.4h; F> 75%. MSC2530818 yerekana kinase nziza cyane, guhitamo ibinyabuzima na selile, imbaraga za microsomal, kandi birashoboka bioavailable. MSC2530818 yerekana imbaraga nuburyo bwo guhitamo kugirango utere imbere muri preclinical muri vivo efficacy nubushakashatsi bwumutekano.

Intego: CDK