BS-181

Izina ryimiti:

N5- (6-aminohexyl) -N7-benzyl-3-isopropylpyrazolo [1,5-a] pyrimidine-5,7-hydrochloride

Kode ya SMILES:

CC (C1 = C2N = C (NCCCCCCN) C = C (NCC3 = CC = CC = C3) N2N = C1) C. [H] Cl

InChi Code:

InChI = 1S / C22H32N6.ClH / c1-17 (2) 19-16-26-28-21 (25-15-18-10-6-5-7-11-18) 14-20 (27-22 ( 19) 28) 24-13-9-4-3-8-12-23; / h5-7,10-11,14,16-17,25H, 3-4,8-9,12-13,15 , 23H2,1-2H3, (H, 24,27); 1H

InChi Urufunguzo:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Ijambo ryibanze:

Gukemura: 

Ububiko: 

Ibisobanuro:

BS-181 ni CDK itoranya cyane ya CDK7 hamwe na IC (50) ya 21 nmol / L. Igeragezwa ryizindi CDK kimwe nizindi kinase 69 zerekanye ko BS-181 yabujije CDK2 gusa yibitekerezo biri munsi ya micromol / L, CDK2 ikabuzwa inshuro 35 imbaraga nke (IC (50) 880 nmol / L) kuruta CDK7. Muri selile MCF-7, BS-181 yabujije fosifora ya CDK7 insimburangingo, iteza imbere ifatwa ry’ingirabuzimafatizo na apoptose kugira ngo ibuze imikurire ya kanseri ya kanseri, kandi yerekana ingaruka za antitumor muri vivo.

Intego: CDK7