Riviciclib

Izina ryimiti:

2-.

Kode ya SMILES:

O = C1C = C (C2 = CC = CC = C2Cl) OC3 = C1C (O) = CC (O) = C3 [C @ H] 4 [C @ H] (CO) N (C) CC4. [H] Cl

InChi Code:

InChI = 1S / C21H20ClNO5.ClH / c1-23-7-6-12 (14 (23) 10-24) 19-15 (25) 8-16 (26) 20-17 (27) 9-18 (28- 21 (19) 20) 11-4-2-3-5-13 (11) 22; / h2-5,8-9,12,14,24-26H, 6-7,10H2,1H3; 1H / t12 -, 14 +; / m1./s1

InChi Urufunguzo:

OOVTUOCTLAERQD-OJMBIDBESA-N

Ijambo ryibanze:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Gukemura: 

Ububiko: 

Ibisobanuro:

Riviciclib, izwi kandi nka P276-00, ni flavone na cyclin biterwa na kinase (CDK) inhibitor hamwe nibikorwa bya antineoplastique. P276-00 guhitamo guhuza no kubuza Cdk4 / cyclin D1, Cdk1 / cyclin B na Cdk9 / cyclin T1, serine / threonine kinase igira uruhare runini mugutunganya ingirabuzimafatizo no gukwirakwiza selile. Kubuza izo kinase biganisha ku gufatwa kwingirangingo mugihe cyinzibacyuho ya G1 / S, bityo bigatuma habaho kwinjiza apoptose, no kubuza ikwirakwizwa rya selile.

Intego: CDK