NTN21277

Izina ryimiti:

(2S, 4R) -1 - ((S) -2- (3- (2 - ((5 - ((4 - ((3 oxy) pentyl) oxy) ethoxy) propanamido) -3,3-dimethylbutanoyl) -4-hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide

Kode ya SMILES:

O = C ([C @ H] 1N (C ([C @@ H] (NC (CCOCCOCCCCCOC2 = CC3 = C (NC4 = CC = C (F) C (Cl) = C4) N = CN = C3C = C2OC ) = O) C (C) (C) C) = O) C [C @ H] (O) C1) NCC5 = CC = C (C6 = C (C) N = CS6) C = C5

InChi Code:

InChI = 1S / C47H57ClFN7O8S / c1-29-42 (65-28-53-29) 31-11-9-30 (10-12-31) 25-50-45 (59) 38-22-33 (57) 26-56 (38) 46 (60) 43 (47 (2,3) 4) 55-41 (58) 15-18-63-20-19-62-16-7-6-8-17-64- 40-23-34-37 (24-39 (40) 61-5) 51-27-52-44 (34) 54-32-13-14-36 (49) 35 (48) 21-32 / h9- 14,21,23-24,27-28,33,38,43,57H, 6-8,15-20,22,25-26H2,1-5H3, (H, 50,59) (H, 55, 58) (H, 51,52,54) / t33-, 38 +, 43- / m1 / s1

InChi Urufunguzo:

NICKHWYZMNLEPJ-TZSMONEZSA-N

Ijambo ryibanze:

Gefitinib ishingiye kuri PROTAC 3; NTN21277; NTN-21277; NTN 21277

Gukemura: 

Ububiko: 

Ibisobanuro:

NTN21277, izwi kandi nka PROTAC 3 ishingiye kuri Gefitinib ni PROTAC itoranya VHL itera kwangirika kwa EGFR na EGFR hamwe na DC50 ya 11.7 nM na 22.3 nM kuri selire HCC827 (Exon 19 del) na selire H3255 (L858R).

Intego: EGFR