EAI-045

Izina ryimiti:

2- (5-fluoro-2-hydroxyphenyl) -2- (3-oxo-1H-isoindol-2-yl) -N- (1,3-thiazol-2-yl) acetamide

Kode ya SMILES:

O = C (NC1 = NC = CS1) C (C2 = CC (F) = CC = C2O) N3CC4 = C (C = CC = C4) C3 = O

InChi Code:

InChI = 1S / C19H14FN3O3S / c20-12-5-6-15 (24) 14 (9-12) 16 (17 (25) 22-19-21-7-8-27-19) 23-10-11- 3-1-2-4-13 (11) 18 (23) 26 / h1-9,16,24H, 10H2, (H, 21,22,25)

InChi Urufunguzo:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

Ijambo ryibanze:

EAI-045, EAI045, EAI 045, 1942114-09-1

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

EAI045 ia inhbitor ikomeye kandi ihitamo EGFR. EAI045 yibasiye imiti yatoranijwe irwanya imiti ya EGFR ariko irinda imiti yo mu gasozi. EAI045 ibuza L858R / T790M-mutant EGFR hamwe nimbaraga nke za nanomolar mubushakashatsi bwibinyabuzima.

Intego: EGFR