AZD-3409

Izina ryimiti:

(S) -isopropyl 2- (2- (4-fluorophenethyl) -5 - (((2 butanoate

Kode ya SMILES:

O = C (OC (C) C) [C @@ H] (NC (C1 = CC (NC [C @ H] 2NC [C @@ H] (SC (C3 = CN = CC = C3) = O) C2) = CC = C1CCC4 = CC = C (F) C = C4) = O) CCSC

InChi Code:

InChI = 1S / C34H41FN4O4S2 / c1-22 (2) 43-33 (41) 31 (14-16-44-3) 39-32 (40) 30-18-27 (13-10-24 (30) 9- 6-23-7-11-26 (35) 12-8-23) 37-20-28-17-29 (21-38-28) 45-34 (42) 25-5-4-15-36- 19-25 / h4-5,7-8,10-13,15,18-19,22,28-29,31,37-38H, 6,9,14,16-17,20-21H2,1- 3H3, (H, 39,40) / t28-, 29-, 31- / m0 / s1

InChi Urufunguzo:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Ijambo ryibanze:

AZD3409; AZD-3409; AZD 3409

Gukemura: 

Ububiko: 

Ibisobanuro:

AZD-3409 nimbaraga zikomeye zo kwimura prenyl. AZD-3409 yerekanye imbaraga zisumba lonafarnib. Hagati ya IC (50) kuri cytotoxicity ya AZD3409 yari 510 mu tugari twa MEF, 10,600 muri selile A549 na 6.170 muri selile MCF7. Muri utwo tugari, IC (50) kubikorwa bya FTase ya AZD3409 yavuye kuri 3.0 kugeza 14.2 nM na lonafarnib kuva 0.26 kugeza 31.3 nM. AZD3409 ibuza farnesylation kurwego rwo hejuru kuruta geranylgeranylation. Byombi kubuza farnesylation na geranylgeranylation ntibishobora guhuzwa nibikorwa bya antiproliferative yibiyobyabwenge. AZD3409 irashobora gukora muri kanseri yamabere irwanya gefitinib.

Intego: prenyl transfert inhibitor