JBJ-04-125-02 R-isomer

Izina ryimiti:

(R) -2- (5-fluoro-2-hydroxyphenyl) -2- (1-oxo-6- (4- -yl) acetamide

Kode ya SMILES:

O = C ([C @ H] (N (C1 = O) CC2 = C1C = C (C = C2) C3 = CC = C (C = C3) N4CCNCC4) C5 = CC (F) = CC = C5O) NC6 = NC = CS6

InChi Code:

InChI = 1S / C29H26FN5O3S / c30-21-5-8-25 (36) 24 (16-21) 26 (27 (37) 33-29-32-11-14-39-29) 35-17-20- 2-1-19 (15-23 (20) 28 (35) 38) 18-3-6-22 (7-4-18) 34-12-9-31-10-13-34 / h1-8, 11,14-16,26,31,36H, 9-10,12-13,17H2, (H, 32,33,37) / t26- / m1 / s1

InChi Urufunguzo:

VHQVOTINPRYDAO-AREMUKBSSA-N

Ijambo ryibanze:

Gukemura: 

Ububiko: 

Ibisobanuro:

JBJ-04-125-02 ni mutant-uhitamo EGFR allosteric inhibitor hamwe nibikorwa bya anticancer. Nkumukozi umwe, irashobora kubuza ikwirakwizwa rya selile na EGFRL858R / T790M / C797S yerekana muri vitro no muri vivo. Guhuza osimertinib na JBJ-04-125-02 bituma habaho kwiyongera kwa apoptose, kubuza cyane gukura kwingirabuzimafatizo, no kongera imbaraga muri vitro no muri vivo ugereranije numukozi umwe wenyine.

Intego: EGFR