AZD-5069

Izina ryimiti:

N- (2 - ((2,3-difluorobenzyl) thio) -6 - (((2R, 3S) -3,4-dihydroxybutan-2-yl) oxy) pyrimidin-4-yl) azetidine-1-sulfonamide

Kode ya SMILES:

O = S (N1CCC1) (NC2 = NC (SCC3 = CC = CC (F) = C3F) = NC (O [C @ H] (C) [C @@ H] (O) CO) = C2) = O

InChi Code:

InChI = 1S / C18H22F2N4O5S2 / c1-11 (14 (26) 9-25) 29-16-8-15 (23-31 (27,28) 24-6-3-7-24) 21-18 (22- 16) 30-10-12-4-2-5-13 (19) 17 (12) 20 / h2,4-5,8,11,14,25-26H, 3,6-7,9-10H2, 1H3, (H, 21,22,23) / t11-, 14 + / m1 / s1

InChi Urufunguzo:

QZECRCLSIGFCIO-RISCZKNCSA-N

Ijambo ryibanze:

AZD-5069, AZD5069, AZD 5069, 878385-84-3

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

AZD-5069 ni antagonist ikomeye kandi ihitamo CXCR2 ifite ubushobozi bwo kubuza kwimuka kwa neutrophil mu kirere mu barwayi bafite COPD. AZD-5069 yerekanwe kubuza guhuza radiyo ya CXCL8 na CXCR2 yabantu ifite pIC50 ifite agaciro ka 9.1. Byongeye kandi, AZD5069 yabujije chemotaxis ya neutrophil, hamwe na pA2 ya hafi 9,6, hamwe na molekile ya molekile ya adhesion, hamwe na pA2 ya 6.9, hasubijwe CXCL1. AZD5069 yari buhoro buhoro antagonist ya CXCR2 ifite ingaruka zigihe nubushyuhe bigaragara kuri farumasi no guhuza kinetics. AZD-5069 nayo irashobora kuba ingirakamaro kubarwayi mugihe cyo gutwika.

Intego: CXCR2