Bardoxolone

Izina ryimiti:

(4aS, 6aR, 6bS, 8aR, 12aS, 14aR, 14bS) -1 4a, 5,6,6a, 6b, 7,8,8a, 9,10,12a, 14,14a, 14b-octadecahydropicene-4a-aside aside

Kode ya SMILES:

CC (C) ([C @] (CC [C @@] ([C @@] 1 (CC [C @] 2 (CCC (C) (C [C @] 2 ([C @] 13 [H ])

InChi Code:

InChI = 1S / C31H41NO4 / c1-26 (2) 10-12-31 (25 (35) 36) 13-11-30 (7) 23 (19 (31) 16-26) 20 (33) 14-22- 28 (5) 15-18 (17-32) 24 (34 ) 27 (3,4) 21 (28) 8-9-29 (22,30) 6 / h14-15,19,21,23H, 8-13,16H2,1-7H3, (H, 35,36) / t19-, 21-, 23-, 28-, 29 +, 30 +, 31- / m0 / s1

InChi Urufunguzo:

TXGZJQLMVSIZEI-UQMAOPSPSA-N

Ijambo ryibanze:

Bardoxolone, RTA 402, CCDO, RTA-402, RTA402, 218600-44-3

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

Ibice by'impyiko biva muri Bardoxolone methyl bivurwa ninguge byerekana kugabanuka kwa poroteyine ya megalin nubwo imvugo ya mRNA isa mumatsinda. Kugabanuka kugaragara mumagambo ya poroteyine ya megalin byemezwa nisesengura rya densitometrie, ryerekanye ko ubuyobozi bwa methyl ya Bardoxolone bwagabanije cyane imvugo ya poroteyine ya megalin mu mpyiko. Ubuyobozi bwa Bardoxolone methyl ntabwo bugira ingaruka kuri proteine ​​ya cubiline mu mpyiko cyangwa mRNA imvugo ya cubiline mu mpyiko. Kureka kwa creinine mu nguge byatanze methyl ya Bardoxolone itandukanye cyane n’ibanze no ku nyamaswa zivuwe n’imodoka ku munsi wa 28. Nyuma yiminsi 28 yubuyobozi bwa methyl ya Bardoxolone, inkari za albumin-to-creatinine (UACRs), zagenwe kuva inkari zamasaha 24 gukusanya, byiyongereye cyane ugereranije nibiri mu nyamaswa zakira imodoka. Icyitonderwa, UACRs igabanukaho 53.3% mu nyamaswa zivurwa n’imodoka kandi yiyongereyeho 27.9% mu nguge zavuwe na Bardoxolone methyl [3]. Imbeba z'abagabo C57BL / 6J zitangwa BARD mu kanwa mugihe cyo kugaburira HFD (HFD / BARD), gusa zigaburirwa indyo yuzuye amavuta (HFD), cyangwa kugaburirwa indyo yuzuye amavuta (LFD) ibyumweru 21. Ugereranije nimbeba za LFD, imbeba za HFD zifite ubwiyongere bugaragara mumibare yimiterere ya F4 / 80 (+ 95%; p<0.001), ikumirwa neza na BARD (−50%; p<0.01). Mu buryo nk'ubwo, umubare wa macrophage ya F4 / 80 uri hejuru cyane ku mbeba za HFD kuri 98% (p<0.001) ugereranije n'imbeba za LFD na 32% (p<0.01) ugereranije n'imbeba za HFD / BARD [4].

Intego: Nrf-2