GDC-0077

Izina ryimiti:

(S) -2 - (((2 - ] oxazepin-9-yl) amino) propanamide

Kode ya SMILES:

C [C @@ H] (C (N) = O) NC1 = CC = C (C2 = NC (N3 [C @ H] (C (F) F) COC3 = O) = CN2CCO4) C4 = C1

InChi Code:

InChI = 1S / C18H19F2N5O4 / c1-9 (16 (21) 26) 22-10-2-3-11-13 (6-10) 28-5-4-24-7-14 (23-17 (11) 24) 25-12 (15 (19) 20) 8-29-18 (25) 27 / h2-3,6-7,9,12,15,22H, 4-5,8H2,1H3, (H2,21 , 26) / t9-, 12- / m0 / s1

InChi Urufunguzo:

SGEUNORSOZVTOL-CABZTGNLSA-N

Ijambo ryibanze:

GDC-0077, GDC0077, GDC 0077, 2060571-02-8

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

GDC-0077 ni munwa iboneka kandi ihitamo PI3K inhibitor (IC50 = 0.038 + 0.003 nM) hamwe> guhitamo inshuro 300 kurenza ayandi masomo ya I PI3K. GDC-0077 ikora ibikorwa byayo ihuza ATP ihuza urubuga rwa PI3K, bityo ikabuza fosifora ya PIP2 kugeza PIP3.

Intego: PI3K