GSK2982772
Ibicuruzwa birambuye
Ibicuruzwa
| Ingano | Kuboneka | Igiciro (USD) |
| 100mg | Mububiko | 500 |
| 500mg | Mububiko | 800 |
| 1g | Mububiko | 1200 |
| Ingano nini | Shaka Amagambo | Shaka Amagambo |
Izina ryimiti:
(S) -5-Benzyl-N- (5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo [b] - 4-triazole-3-carboxamide
Kode ya SMILES:
O = C (C1 = NN = C (CC2 = CC = CC = C2) N1) N [C @@ H] 3C (N (C) C4 = CC = CC = C4OC3) = O
InChi Code:
InChI = 1S / C20H19N5O3 / c1-25-15-9-5-6-10-16 (15) 28-12-14 (20 (25) 27) 21-19 (26) 18-22-17 (23- 24-18) 11-13-7-3-2-4-8-13 / h2-10,14H, 11-12H2,1H3, (H, 21,26) (H, 22,23,24) / t14 - / m0 / s1
InChi Urufunguzo:
LYPAFUINURXJSG-AWEZNQCLSA-N
Ijambo ryibanze:
GSK-2982772, GSK 2982772, GSK2982772, 1622848-92-3
Gukemura:Gukemura muri DMSO
Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).
Ibisobanuro:
GSK2982772 ni reseptor ikomeye kandi itoranya Imikoreshereze ya poroteyine 1 (RIP1) Kinase Umukandida wihariye wa Clinical Umukandida wo kuvura indwara zanduza. GSK2982772, kuri ubu, mu cyiciro cya 2a cy’ubuvuzi bwa psoriasis, rubagimpande ya rubagimpande, na kolite y ibisebe. GSK2982772 ihuza cyane na RIP1 hamwe na kinase nziza cyane kandi ifite ibikorwa byiza muguhagarika ibisubizo byinshi bya TNF biterwa na selile. RIP1 yagaragaye nkingirakamaro yo hejuru ya kinase yerekanwe kugenga ibicanwa binyuze muri scafolding na kinase imirimo yihariye.
Intego: RIP1
