Adavivint

Izina ryimiti:

N- (5- {3- [7- (3-fluorophenyl) -1H-imidazo -methylbutanamide

Kode ya SMILES:

CC (C) CC (NC1 = CC (C2 = CC3 = C (NN = C3C (N4) = NC5 = C4C (C6 = CC = CC (F) = C6) = CN = C5) C = C2) = CN = C1) = O.

InChi Code:

InChI = 1S / C29H24FN7O / c1-16 (2) 8-26 (38) 33-21-10-19 (12-31-13-21) 17-6-7-24-22 (11-17) 28 ( 37-36-24) 29-34-25-15-32-14-23 (27 (25) 35-29) 18-4-3-5-20 (30) 9-18 / h3-7,9- 16H, 8H2,1-2H3, (H, 33,38) (H, 34,35) (H, 36,37)

InChi Urufunguzo:

AQDWDWAYVBQMAM-UHFFFAOYSA-N

Ijambo ryibanze:

Adavivint, SM04690, SM-04690, SM 04690, 1467093-03-3

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

Agashya gato molekile Wnt inzira inhibitor hamwe na EC50 ya 3 nM muri vitro; itera itandukanyirizo rya HMSC muburyo bukuze, bukora chondrocytes kandi bugabanya urwego rwa karitsiye ya catabolika; itezimbere cyane Osteoarthritis Research Society International (OARSI) amanota yamateka hamwe na biomarkers muburyo bwa OA.

Intego: WNT