Tropifexor

Izina ryimiti:

2 - ((1R, 3r, 5S) -3 - ((5-cyclopropyl-3- (2- yl) -4-fluorobenzo [d] thiazole-6-aside aside

Kode ya SMILES:

FC (F) (F) OC (C = CC = C1) = C1C2 = NOC (C3CC3) = C2CO [C @@ H] 4C [C @ H] 5N (C6 = NC7 = C (F) C = C ( C (O) = O) C = C7S6) [C @ H] (CC5) C4

InChi Code:

InChI = 1S / C29H25F4N3O5S / c30-21-9-15 (27 (37) 38) 10-23-25 ​​(21) 34-28 (42-23) 36-16-7-8-17 (36) 12- 18 (11-16) 39-13-20-24 (35-41-26 (20) 14-5-6-14) 19-3-1-2-4-22 (19) 40-29 (31, 32) 33 / h1-4,9-10,14,16-18H, 5-8,11-13H2, (H, 37,38) / t16-, 17 +, 18 +

InChi Urufunguzo:

VYLOOGHLKSNNEK-PIIMJCKOSA-N

Ijambo ryibanze:

Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

Tropifexor (compound 1) nigitabo kandi gikomeye cyane agoniste wa FXR hamwe na EC50 ya 0.2 nM. Kwinjiza gukomeye kwa BSEP na SHP byombi bigaragarira mu ngirabuzimafatizo z'ibanze na Tropifexor mu buryo bushingiye ku kwibanda. Kwinjira kwa BSEP hejuru yikinyabiziga (DMSO) bigaragarira mubutumburuke buri munsi ya 1 nM, mugihe kwinjiza cyane kwa SHP (inshuro 15 hejuru yikinyabiziga) bigaragara kuri 10 nM no kwinjiza mu buryo bworoheje SHP kuri 1 nM (inshuro 3) [1 ].

Intego: FXR