RGX-104 HCl
Ibicuruzwa birambuye
Ibicuruzwa
| Ingano | Kuboneka | Igiciro (USD) |
| 100mg | Mububiko | 500 |
| 500mg | Mububiko | 800 |
| 1g | Mububiko | 1200 |
| Ingano nini | Shaka Amagambo | Shaka Amagambo |
Izina ryimiti:
(R) -2- [3- [3 - [[2-Chloro-3- (trifluoromethyl) benzyl]
Kode ya SMILES:
O = C (O) CC1 = CC = CC (OCC [C @ H] (N (CC2 = CC = CC (C (F) (F) F) = C2Cl) CC (C3 = CC = CC = C3) C4 = CC = CC = C4) C) = C1. [H] Cl
InChi Code:
InChI = 1S / C34H33ClF3NO3.ClH / c1-24 (18-19-42-29-16-8-10-25 (20-29) 21-32 (40) 41) 39 (22-28-15-9- 17-31 (33 (28) 35) 34 (36,37) 38) 23-30 (26-11-4-2-5-12-26) 27-13-6-3-7-14-27; /h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41); 1H / t24-; / m1./s1
InChi Urufunguzo:
LCMIYQOJZLRHTO-GJFSDDNBSA-N
Ijambo ryibanze:
RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1
Gukemura:Gukemura muri DMSO
Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).
Ibisobanuro:
RGX-104 ni umwijima X wakira beta agonist ufite ibikorwa byo gukingira no kurwanya antineoplastique. Ku mvugo yo mu kanwa, RGX-104 ihitamo intego kandi ihuza LXRbeta, bityo igakora ibimenyetso byerekana LXRbeta, biganisha ku kwanduza genes zimwe na zimwe zikuraho ibibyimba no kugabanya ingirabuzimafatizo zimwe na zimwe zitera ibibyimba. Ibi bikora cyane cyane imvugo ya apolipoproteine E (ApoE), poroteyine ikuraho ibibyimba, mu ngirabuzimafatizo no mu ngirabuzimafatizo zimwe na zimwe z'umubiri. Ibi bikora sisitemu yubudahangarwa bw'umubiri, bikaviramo kugabanuka kwa immunosuppressive myeloid ikomoka kuri suppressor selile (MDSCs), selile kanseri yibibyimba hamwe na selile endothelia mikorobe yibidukikije. Ibi bihindura kwirinda ubudahangarwa bw'umubiri, byongera ubudahangarwa bw'umubiri urwanya ibibyimba kandi bikabuza ikwirakwizwa ry'uturemangingo tw’ibibyimba.
Intego: LXRbeta
