AZD7507

Izina ryimiti:

4- (2-fluoro-4-methylanilino) -6- [4-

Kode ya SMILES:

O = C (C1 = NN = C2C = C (OC) C (N3CCN (CCO) CC3) = CC2 = C1NC4 = CC = C (C) C = C4F) N

InChi Code:

InChI = 1S / C23H27FN6O3 / c1-14-3-4-17 (16 (24) 11-14) 26-21-15-12-19 (30-7-5-29 (6-8-30) 9- 10-31) 20 (33-2) 13-18 (15) 27-28-22 (21) 23 (25) 32 / h3-4,11-13,31H, 5-10H2,1-2H3, (H2 , 25,32) (H, 26.27)

InChi Urufunguzo:

CPDGCAFPSYOTGO-UHFFFAOYSA-N

Ijambo ryibanze:

AZD7507; AZD-7507; AZD 7507

Gukemura:DMSO

Ububiko: 

Ibisobanuro:

AZD7507 ninzitizi ikomeye kandi ihitamo CSF-1R inhibitor (ibikorwa bya selile 32 nM), AZD7507 ifatwa nkibintu bitanga icyizere kuko yagumanye imbaraga zifuzwa hamwe nubuvuzi bwa farumasi bwa AZ683. Byongeye kandi, mu bushakashatsi bwa telemetrie mu mbwa zahawe ikinini kimwe cyo mu kanwa, nta burozi bw’umutima n’imitsi, nta kuzamuka kwa troponine bifitanye isano no kuvura, kandi nta cyahindutse muri ECG.

Intego: CSF-1R