BI-847325

Izina ryimiti:

(Z) -3- (3 - ((((4 -

Kode ya SMILES:

O = C (NCC) C # CC1 = CC (NC / 2 = O) = C (C = C1) C2 = C (NC3 = CC = C (CN (C) C) C = C3) / C4 = CC = CC = C4

InChi Code:

InChI = 1S / C29H28N4O2 / c1-4-30-26 (34) 17-13-20-12-16-24-25 (18-20) 32-29 (35) 27 (24) 28 (22-8- 6-5-7-9-2 2) 31-23-14-10-21 (11-15-23) 19-33 (2) 3 / h5-12,14-16,18,31H, 4,19H2,1-3H3, (H, 30 , 34) (H, 32,35) / b28-27-

InChi Urufunguzo:

FLBNLJLONKAPLR-DQSJHHFOSA-N

Ijambo ryibanze:

BI-847325, BI847325, BI 847325, 1207293-36-4

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

BI-847325 ni indobanure ya MEK / Aurora kinase inhibitor ifite indangagaciro za IC50 zifite agaciro ka 3, 25, 15, 25, na 4 nM kuri X. laevis Aurora B, abantu Aurora A na Aurora C, hamwe na MEK1 na MEK2. Irashobora kubuza gukura no kubaho byombi kuvura-naive ndetse no kurwanya imiti ya selile ya melanoma, bikagabanya imvugo ya MEK na Mcl-1 mugihe byongera imvugo ya poroteyine Bim-apoptotique Bim. Kuri mg / kg 70, BI-847325 itera apoptose mu kuvura-naive kandi irwanya ibiyobyabwenge xenografted melanoma muri vivo.

Intego: MEK / Aurora