JBJ-04-125-02 R-isomer
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
Dzina la Chemical:
(R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2 -yl) acetamide
SMILES Kodi:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
InChi kodi:
InChI=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19(15-23(20)28(35)38)18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8, 11,14-16,26,31,36H,9-10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
InChi Key:
VHQVOTINPRYDAO-AREMUKBSSA-N
Mawu ofunika:
Kusungunuka:
Posungira:
Kufotokozera:
JBJ-04-125-02 ndi mutant-selective EGFR allosteric inhibitor yokhala ndi ntchito yolimbana ndi khansa. Monga wothandizira m'modzi, imatha kuletsa kuchuluka kwa ma cell ndi EGFRL858R/T790M/C797S signing in vitro and in vivo. Kuphatikizika kwa osimertinib ndi JBJ-04-125-02 kumabweretsa kuwonjezeka kwa apoptosis, kulepheretsa kogwira mtima kwa kukula kwa ma cell, komanso kuwonjezereka kwamphamvu mu vitro ndi mu vivo poyerekeza ndi wothandizira mmodzi yekha.
Cholinga: EGFR
