TH-302; Evofosfamide
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 360 |
| 1g | Zilipo | 1000 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
SMILES Kodi:
O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C
InChi kodi:
InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)
InChi Key:
UGJWRPJDTDGERK-UHFFFAOYSA-N
Mawu ofunika:
TH-302, TH302, TH 302, Evofosfamide, 918633-87-1
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)
Kufotokozera:
Evofosfamide, yomwe imadziwikanso kuti TH-302, ndi mankhwala opangidwa ndi hypoxia omwe amakhala ndi 2-nitroimidazole phosphoramidate conjugate yokhala ndi mphamvu yoletsa antiineoplastic. 2-nitroimidazole moiety ya hypoxia-activated prodrug TH-302 imakhala ngati hypoxic trigger, kutulutsa DNA-alkylating dibromo isophosphoramide mpiru moiety mkati hypoxic zigawo zotupa. Minofu ya Normoxic ikhoza kupulumutsidwa chifukwa cha zochita za hypoxia yeniyeni ya wothandizira uyu, zomwe zingathe kuchepetsa kawopsedwe kazinthu. Yang'anani mayesero azachipatala omwe akugwira ntchito kapena mayesero otsekedwa achipatala pogwiritsa ntchito wothandizira uyu. (NCI).
Cholinga: DNA Alkylating Agent
