AZD7507

Dzina la Chemical:

4-(2-fluoro-4-methylanilino) -6--[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide

SMILES Kodi:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

InChi kodi:

InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31 )20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2,25, 32) (H,26,27)

InChi Key:

CPDGCAFPSYOTGO-UHFFFAOYSA-N

Mawu ofunika:

AZD7507; AZD-7507; Mtengo wa AZD7507

Kusungunuka:DMSO

Posungira: 

Kufotokozera:

AZD7507 ndi yamphamvu komanso yosankha CSF-1R inhibitor (32 nM cell zochita), AZD7507 imadziwika kuti ndi yodalirika chifukwa idasungabe mphamvu zomwe zimafunidwa komanso zapakamwa za pharmacokinetic za AZ683. Komanso, mu kafukufuku wa telemetry mu agalu omwe anapatsidwa mlingo umodzi wapakamwa, panalibe poizoni wamtima, palibe kukwera kwa troponin zokhudzana ndi chithandizo, komanso kusintha kwa ECG.

Cholinga: CSF-1R