AZD8186
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 350 |
| 500 mg | Zilipo | 700 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(R) -8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide
SMILES Kodi:
O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1
InChi kodi:
InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3 )9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14 -/m1/s1
InChi Key:
LMJFJIDLEAWOQJ-CQSZACIVSA-N
Mawu ofunika:
AZD8186, AZD-8186, AZD 8186, 1627494-13-6
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)
Kufotokozera:
AZD8186 ndi inhibitor ya beta isoform ya phosphoinositide-3 kinase (PI3K), yokhala ndi ntchito yoletsa antiineoplastic. Poyang'anira, PI3Kbeta inhibitor AZD8186 mosankha imalepheretsa ntchito ya PI3Kbeta mu njira yowonetsera PI3K/Akt/mTOR, zomwe zingapangitse kuchepa kwa kuchuluka kwa maselo otupa. Zimayambitsanso kufa kwa ma cell mu ma cell a khansa a PI3K. Poyang'ana makamaka beta ya kalasi I PI3K, wothandizira uyu atha kukhala wogwira mtima komanso wopanda poizoni kuposa ma pan PI3K inhibitors. Kuzindikiritsa kwapakati pa PI3K nthawi zambiri kumayendetsedwa m'maselo a khansa ndipo kumathandizira kukulitsa kukula kwa maselo a chotupa, kupulumuka, komanso kukana chotupa kumitundu yosiyanasiyana ya antineoplastic. AZD8186 pano ili pansi pa mayeso achipatala a Phase I.
Cholinga: PI3K
