diABZI STING agonist-1

Kjemisk navn:

(E)-1-(4-(5-karbamoyl-2-(1-etyl-3-metyl-1H-pyrazol-5-karboksamido)-7-(3-morfolinopropoksy)-1H-benzo[d]imidazol -1-yl)but-2-en-1-yl)-2-(1-etyl-3-metyl-1H-pyrazol-5-karboksamido)-7-metoksy-1H-benzo[d]imidazol-5- karboksamid

SMILES-kode:

O=C(N)C1=CC(N=C(NC(C2=CC(C)=NN2CC)=O)N3C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O) =NC6=C4C(OCCCN7CCOCC7)=CC(C(N)=O)=C6)=C3C(OC)=C1

InChi-kode:

InChI=1S/C42H51N13O7/c1-6-54-31(19-25(3)49-54)39(58)47-41-45-29-21-27(37(43) )56)23-33(60-5)35(29)52(41)12-8-9-13-53-36-30(46-42(53)48-40(59)32-20-26 (4) 50-55(32)7-2)22-28(38(44)57)24-34(36)62-16-10-11-51-14-17-61-18-15-51/h8- 9, 19-24H,6-7,10-18H2,1-5H3,(H2,43,56)(H2,44,57)(H,45,47,58)(H,46,48,59)/b9 -8+

InChi-nøkkel:

JGLMVXWAHNTPRF-CMDGGOBGSA-N

Nøkkelord:

Løselighet: 

Lagring: 

Beskrivelse:

diaBZI STING agonist-1 er en selektiv stimulator av interferon gener (STING) reseptor agonist, med EC50s på 130, 186 nM for henholdsvis mennesker og mus.

Mål: STING