TH-302; Evofosfamide

Ingoa matū:

N,N'-Bis(2-bromoethyl) phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester

Waehere SMILES:

O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C

Waehere InChi:

InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)

Kī InChi:

UGJWRPJDTDGERK-UHFFFAOYSA-N

Kupumatua:

TH-302, TH302, TH 302, Evofosfamide, 918633-87-1

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)

Whakaahuatanga:

Ko te Evofosfamide, e mohiotia ana ko TH-302, he prodrug-whakahohe hypoxia kei roto i te 2-nitroimidazole phosphoramidate conjugate me te mahi antineoplastic pea. Ko te 2-nitroimidazole moiety o hypoxia-whakahohehia prodrug TH-302 mahi hei keu hypoxic, tuku i te DNA-alkylating dibromo isophosphoramide moiety pua nani i roto i nga rohe hypoxic o nga pukupuku. Ka tohungia pea nga kopa Normoxic na te mahi hypoxia-motuhake a tenei kaihoko, ka whakaiti pea i te paitini o te punaha. Tirohia mo nga whakamatautau haumanu kaha, nga whakamatautau haumanu kati ranei ma te whakamahi i tenei kaihoko. (NCI).

Whāinga: DNA Alkylating Agent