AZD7507

Ingoa matū:

4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide

Waehere SMILES:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

Waehere InChi:

InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31 )20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2,25, 32)(H,26,27)

Kī InChi:

CPDGCAFPSYOTGO-UHFFFAOYSA-N

Kupumatua:

AZD7507; AZD-7507; AZD 7507

Wairewa:DMSO

Rokiroki: 

Whakaahuatanga:

Ko te AZD7507 he aukati CSF-1R kaha me te whiriwhiri (32 nM mahi pūtau), e kiia ana ko AZD7507 he pūhui whai hua i te mea e mau tonu ana te kaha e hiahiatia ana me nga taonga pharmacokinetic waha o AZ683. I tua atu, i roto i te rangahau telemetry i nga kuri i whakawhiwhia ki te horopeta a-waha kotahi, karekau he paitini o te ngakau, karekau he pikinga o te troponin e pa ana ki te maimoatanga, kaore he whakarereketanga o te ECG.

Whāinga: CSF-1R