BI-847325

Ingoa matū:

(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide

Waehere SMILES:

O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4

Waehere InChi:

InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-2 2)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2,1-3H3,(H,30 ,34)(H,32,35)/b28-27-

Kī InChi:

FLBNLJLONKAPLR-DQSJHHFOSA-N

Kupumatua:

BI-847325, BI847325, BI 847325, 1207293-36-4

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)

Whakaahuatanga:

Ko te BI-847325 he mea whiriwhiringa rua MEK / Aurora kinase inhibitor me nga uara IC50 o 3, 25, 15, 25, me 4 nM mo X. laevis Aurora B, Aurora A me Aurora C, me te MEK1 me te MEK2 tangata. Ka taea e ia te aukati i te tipu me te oranga o nga raina pūtau melanoma e rua mo te maimoatanga-kore me te aukati i te tarukino, te whakaheke i te whakahuatanga o MEK me Mcl-1 i te wa e whakanui ana te whakaaturanga o te Bim protein pro-apoptotic. I te 70 mg/kg, BI-847325 ka whakaawe i te apoptosis i roto i te melanoma xenografted maimoatanga-naive me te tarukino-aukati i roto i te vivo.

Whāinga: MEK/Aurora