Vactosertib

Ingoa matū:

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl )-2-fluoroaniline

Waehere SMILES:

FC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2

Waehere InChi:

InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12- 15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29 )

Kī InChi:

FJCDSQATIJKQKA-UHFFFAOYSA-N

Kupumatua:

Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)

Whakaahuatanga:

Ko te Vactosertib, e mohiotia ana ko EW-7197 he kaha te aukati ALK5. I whakaatu a EW-7197 i te kaha o te mahi anti-metastatic in vivo, e tohu ana i tona kaha ki te whakamahi hei rongoa mate pukupuku. Ko te EW-7197 ka whakakore i te tohu TGF-β / Smad. Ka whakakorehia e EW-7197 te hekenga me te whakaekenga a TGF-β1. Ko te EW-7197 te aukati i te metastasis o te mate pukupuku o te uma ki te puha. Ko te EW-7197 te aukati i te metastasis me te whakarei ake i te mahi o te cytotoxic T lymphocytes (CTLs) i roto i te 4T1 orthotopic kiore honoa.

Whāinga: ALK