TAS-120
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Nomen chemicum:
1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl] -2-propen-1-one
SMILES Code:
C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O
InChi Code:
InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5-14-9-16(30-2)11-17(10-14) 31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2 ,23,24,25)/t15-/m0/s1
InChi Key:
KEIPNCCJPRMIAX-HNNXBMFYSA-N
Keyword:
TAS-120
Solubilitas:
Repono:
Descriptio:
TAS-120 est ore bioavailable inhibitor incrementi fibroblast factoris receptoris (FGFR) cum actuositate antineoplastica potentiale. FGFR inhibitor TAS-120 selective et irrevocabiliter ligat et vetat FGFR, quod potest in inhibitione utriusque FGFR mediatae signo transductionis pervium et tumorem cellularum prolificationis, et auctam mortem cellularum in FGFR-excellentium cellularum tumorem. FGFR recepta tyrosine kinase essentialis est ad tumorem cellularum multiplicationem, differentiam et superstitem, eiusque expressio in multis generibus cellularum tumore upregulata est.
Target: FGFR