BLU-667

BLU-667
  • Nomen:BLU-667
  • Catalogue No.CPD2049
  • CAS No.:2097132-94-8
  • Pondus hypotheticum:532.27
  • Formulae chemica:C28H33FN8O2
  • Investigationes scientificae tantum, non aegros.

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    Nomen chemicum:

    (1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pyrazol-1-yl) phenyl)ethyl)-1-methoxy-4-(4-methyl-6-( (5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide

    SMILES Code:

    CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

    InChi Code:

    InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4; 12-10-21 27(38)32-19(3)20-5 -7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13-16,19,21H,9-12H2,1-4H3,(H,32; 38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

    InChi Key:

    HUQPYQIGHTXBNW-BDHWGLMFSA-N

    Keyword:

    BLU-667; BLU 667; BLU667

    Solubilitas:DMSO

    Repono: 

    Descriptio:

    BLU-667 potens et selectivus inhibitor ret mutationum, fusionum, praedixit resistens mutantes. RET fusiones sunt aurigae clavium plurium carcinomata, inclusa pulmonis et cancri thyroideae, et investigatio nostra suggerit RET etiam praecipuum munus in quibusdam carcinomatis colon et pectoris habere. Eodem tempore target primarium coegi et repugnant mutantes praedixit, qui cancer cellas sentientes curationem reddunt cum medicamentis currently probatis;

    Target: RET


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