BI-847325
Product Detail
Product Tags
| Pack Size | Availability | Pretium (USD) |
| 100mg | In Stock | 400 |
| 500mg | In Stock | 950 |
| 1g | In Stock | 1400 |
| Plus Sizes | Get Quotes | Get Quotes |
Nomen chemicum:
(Z) -3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
SMILES Code:
O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4
InChi Code:
InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2; 1-3H3,(H,30,34)(H,32,35)/b28-27-
InChi Key:
FLBNLJLONKAPLR-DQSJHHFOSA-N
Keyword:
BI-847325, BI847325, BI 847325, 1207293-36-4
Solubilitas:Solutum in DMSO
Repono:0 - 4° C pro brevi termino (dies ad hebdomades), vel -20° C ad terminum longum (menses)
Descriptio:
BI-847325 inhibitor kinase inhibitor dualis MEK/Aurora cum IC50 valores 3, 25, 15, 25, et 4 nM pro X laevis Aurora B, humana Aurora A et Aurora C, humana MEK1 et MEK2, respectively. Inhibere potest incrementum et salutem utriusque curationis rusticae et pharmacopolae resistentis melanomatis cellae lineae, expressionem MEK et Mcl-1 decrescentem, dum expressionem dapibus apoptoticis pro-apoptoticis augere. Ad 70 mg/kg, BI-847325 apoptosin inducit in curatione melanoma-navorum et medicamento repugnanti in vivo.
Target: MEK/Aurora
