SEL120-34A

Jeneng Kimia:

7,8-Dibromo-9-metil-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline Hydrochloride

Kode SMILES:

CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl

Kode Inchi:

InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20;/h18H,2-8H2,1H3;1H

Kunci InChi:

GQXLWUCQESKBSC-UHFFFAOYSA-N

tembung kunci:

SEL120-34A; SEL 120-34A; SEL-120-34A; SEL12034A; SEL 12034A; SEL-12034A

Kelarutan: 

Panyimpenan: 

katrangan:

SEL120-34A minangka inhibitor CDK8 sing kuat lan selektif aktif ing sel AML kanthi tingkat fosforilasi serin sing dhuwur saka domain transaktivasi STAT1 lan STAT5. EL120-34A nyegah fosforilasi STAT1 S727 lan STAT5 S726 ing sel kanker in vitro. Secara konsisten, regulasi transkripsi gumantung saka STAT- lan NUP98-HOXA9 wis diamati minangka mekanisme tumindak sing dominan ing vivo.

Sasaran: CDK8