Riviciclib

Jeneng Kimia:

2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride

Kode SMILES:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

Kode Inchi:

InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28- 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

Kunci InChi:

OOVTUOCTLAERQD-OJMBIDBESA-N

tembung kunci:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Kelarutan: 

Panyimpenan: 

katrangan:

Riviciclib, uga dikenal minangka P276-00, minangka inhibitor kinase gumantung saka flavon lan cyclin (CDK) kanthi aktivitas antineoplastik potensial. P276-00 kanthi selektif ngiket lan nyegah Cdk4 / cyclin D1, Cdk1 / cyclin B lan Cdk9 / cyclin T1, serine / threonine kinase sing nduweni peran penting ing regulasi siklus sel lan proliferasi seluler. Inhibisi kinase kasebut nyebabake penahanan siklus sel sajrone transisi G1 / S, saengga nyebabake induksi apoptosis, lan nyegah proliferasi sel tumor.

Sasaran: CDK