Voruciclib

Jeneng Kimia:

2-(2-Chloro-4-(trifluoromethyl)fenil)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-1-benzopyran -4-siji

Kode SMILES:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

Kode Inchi:

InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21( 1 9)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

Kunci InChi:

MRPGRAKIAJJGMM-OCCSQVGLSA-N

tembung kunci:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Kelarutan: 

Panyimpenan: 

katrangan:

Voruciclib, uga dikenal minangka P1446A-05, minangka inhibitor protein kinase khusus kanggo kinase 4 (CDK4) sing gumantung karo cyclin kanthi aktivitas antineoplastik potensial. Inhibitor CDK4 P1446A-05 khusus nyegah transisi fase G1-S sing dimediasi CDK4, nyegah siklus sel lan nyegah pertumbuhan sel kanker. Serine/threonine kinase CDK4 ditemokake ing kompleks kanthi siklik G1 tipe D lan minangka kinase pisanan sing diaktifake nalika stimulasi mitogenik, ngeculake sel saka tahap diam menyang tahap siklus pertumbuhan G1 / S; Kompleks CDK-siklin wis ditampilake kanggo fosforilasi faktor transkripsi retinoblastoma (Rb) ing awal G1, ngganti histone deacetylase (HDAC) lan ngalangi represi transkripsi.

Sasaran: CDK4