LDC000067

Jeneng Kimia:

3-[[6-(2-Methoxyphenyl)-4-pirimidinyl]amino]benzenemethanesulfonamide

Kode SMILES:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

Kode Inchi:

InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6 -4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

Kunci InChi:

GGQCIOOSELPMBB-UHFFFAOYSA-N

tembung kunci:

LDC000067; LDC-000067; LDC 000067

Kelarutan: 

Panyimpenan: 

katrangan:

LDC000067 minangka inhibitor CDK9 sing kuat lan selektif. LDC000067 nyandhet transkripsi in vitro kanthi cara ATP-kompetitif lan gumantung dosis. Profil ekspresi gen sel sing diobati karo LDC000067 nuduhake pengurangan selektif mRNA sing umure cendhak, kalebu regulator penting proliferasi lan apoptosis. Analisis sintesis RNA de novo nyaranake peran positif CDK9. Ing tingkat molekuler lan seluler, LDC000067 ngasilake efek karakteristik saka inhibisi CDK9 kayata ngaso RNA polimerase II ing gen lan, sing paling penting, induksi apoptosis ing sel kanker. LDC000067 nyegah transkripsi in vitro gumantung P-TEFb. Nimbulake apoptosis in vitro lan in vivo kanthi kombinasi BI 894999.

Sasaran: CDK9