Alvocidib

Jeneng Kimia:

2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one

Kode SMILES:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

Kode Inchi:

InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(28-21) 19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17 +/m1/s1

Kunci InChi:

BIIVYFLTOXDAOV-PXAZEXFGSA-N

tembung kunci:

L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib

Kelarutan: 

Panyimpenan: 

katrangan:

Alvocidib minangka senyawa sintetik N-methylpiperidinyl chlorophenyl flavone. Minangka inhibitor kinase sing gumantung karo cyclin, alvocidib ngindhuksi penahanan siklus sel kanthi nyegah fosforilasi kinase gumantung cyclin (CDKs) lan ekspresi cyclin D1 lan D3 sing ngatur mudhun, nyebabake penahanan siklus sel G1 lan apoptosis. Agen iki uga minangka inhibitor kompetitif aktivitas adenosin trifosfat. Priksa uji klinis aktif utawa uji klinis tertutup nggunakake agen iki.

Sasaran: CDK