BS-181
Detail Produk
Tag produk
Ukuran Paket | kasedhiyan | Rega (USD) |
Jeneng Kimia:
N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pirimidine-5,7-diamine hydrochloride
Kode SMILES:
CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl
Kode Inchi:
InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22( 19)28 )24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2, 1-2H3,(H,24,27);1H
Kunci InChi:
NVIJWMOQODWNFN-UHFFFAOYSA-N
tembung kunci:
Kelarutan:
Panyimpenan:
katrangan:
BS-181 minangka inhibitor CDK sing selektif banget kanggo CDK7 kanthi IC(50) 21 nmol/L. Pengujian CDK liyane uga 69 kinase liyane nuduhake yen BS-181 mung nyandhet CDK2 ing konsentrasi sing luwih murah tinimbang 1 mikromol/L, kanthi CDK2 dicegah 35 kali lipat kurang kuat (IC(50) 880 nmol/L) tinimbang CDK7. Ing sel MCF-7, BS-181 nyandhet fosforilasi substrat CDK7, ningkatake penahanan siklus sel lan apoptosis kanggo nyegah pertumbuhan garis sel kanker, lan nuduhake efek antitumor ing vivo.
Sasaran: CDK7