NTN21277

Jeneng Kimia:

(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl))amino)))-7-metoxyquinazolin-6-yl) oksi) pentil) oksi). oksi) propanamido)-3,3-dimetilbutanoil)-4-hidroksi-N-(4-(4-metiltiazol-5-yl)benzil)pirolidin-2-karbokamide

Kode SMILES:

O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N =CN=C3C=C2OC)=O)C(C)(C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C =C5

Kode Inchi:

InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-3 3(57)26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8- 17-64-40-23-34-37 (24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9-14,21,23-24 ,27-28,33,3 8,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)/t33- ,38+,43-/m1/s1

Kunci InChi:

NICKHWYZMNLEPJ-TZSMONEZSA-N

tembung kunci:

PROTAC 3 adhedhasar Gefitinib; NTN21277; NTN-21277; NTN 21277

Kelarutan: 

Panyimpenan: 

katrangan:

NTN21277, uga dikenal minangka PROTAC basis Gefitinib 3 yaiku PROTAC sing merekrut VHL sing nyebabake degradasi mutan EGFR lan EGFR kanthi DC50 saka 11,7 nM lan 22,3 nM kanggo sel HCC827 (Exon 19 del) lan sel H3255 (L858R).

Sasaran: EGFR