JBJ-04-125-02 R-isomer
Detail Produk
Tag produk
| Ukuran Paket | kasedhiyan | Rega (USD) |
Jeneng Kimia:
(R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)fenil)isoindolin-2-yl)-N-(thiazol-2 -yl) asetamida
Kode SMILES:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
Kode Inchi:
InChI=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19(15-23(20)28( 35)38)18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8,11,14-16,26,31,36H,9- 10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
Kunci InChi:
VHQVOTINPRYDAO-AREMUKBSSA-N
tembung kunci:
Kelarutan:
Panyimpenan:
katrangan:
JBJ-04-125-02 minangka inhibitor alosterik EGFR selektif mutant kanthi aktivitas antikanker potensial. Minangka agen tunggal, bisa nyandhet proliferasi sel lan sinyal EGFRL858R/T790M/C797S in vitro lan in vivo. Kombinasi osimertinib lan JBJ-04-125-02 nyebabake paningkatan apoptosis, inhibisi pertumbuhan sel sing luwih efektif, lan efektifitas tambah in vitro lan in vivo dibandhingake karo agen tunggal.
Sasaran: EGFR
