AZD-3409

Jeneng Kimia:

(S)-isopropil 2-(2-(4-fluorophenethyl)-5-((((2S,4S)-4-(nicotinoylthio)pyrrolidin-2-yl)metil)amino)benzamido)-4-(methylthio) butanoat

Kode SMILES:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

Kode Inchi:

InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30-18-27(13-10-24(30)9- 6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38-28)45-34(42)25-5-4-15-36- 19-25/h4-5,7-8,10-13,15,18-19,22,28-29,31,37-38H,6,9,14,16-17,20-21H2,1- 3H3,(H,39,40)/t28-,29-,31-/m0/s1

Kunci InChi:

HKGUHEGKBLYKHY-QMOZSOIISA-N

tembung kunci:

AZD3409; AZD-3409; AZD 3409

Kelarutan: 

Panyimpenan: 

katrangan:

AZD-3409 minangka inhibitor prenyl transferase sing kuat. AZD-3409 nuduhake potency luwih saka lonafarnib. Rata-rata IC(50) kanggo sitotoksisitas AZD3409 yaiku 510 ing sel MEF, 10.600 ing sel A549 lan 6.170 ing sel MCF7. Ing sel kasebut, IC (50) kanggo aktivitas FTase saka AZD3409 antara 3,0 nganti 14,2 nM lan lonafarnib saka 0,26 nganti 31,3 nM. AZD3409 nyegah farnesylation luwih dhuwur tinimbang geranylgeranylation. Loro-lorone inhibisi farnesylation lan geranylgeranylation ora bisa digandhengake karo aktivitas antiproliferatif obat kasebut. AZD3409 bisa uga aktif ing karsinoma payudara sing tahan gefitinib.

Target: inhibitor prenyl transferase