NTN21277
Nkọwa ngwaahịa
Mkpado ngwaahịa
| Nha ngwugwu | Nnweta | Ọnụ ego (USD) |
Aha kemịkalụ:
(2S, 4R) -1-((S) -2- (3- (2- ((5-- ((4-- (3-chloro-4-fluorophenyl)))-7-methoxyquinazolin-6-yl) oxy) pentyl) oxy) ethoxy) propanamido) -3,3-dimethylbutanoyl) -4-hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide
Koodu Ọchịchọ:
O=C([C@H]1N(C([C@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC ==O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Koodu InChi:
InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-3 3 (57) 26-56 (38) 46 (60) 43 (47 (2,3)4) 55-41 (58) 15-18-63-20-19-62-16-7-6-8- 17-64-40-23-34-37 (24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9-14,21,23-24 ,27-28,33,3 8,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)/t33- ,38+,43-/m1/s1
Igodo InChi:
NICKHWYZMNLEPJ-TZSMONEZSA-N
Okwu:
Gefitinib dabeere PROTAC 3; NTN21277; NTN-21277; NTN 21277
Solubility:
Nchekwa:
Nkọwa:
NTN21277, makwaara dị ka Gefitinib dabeere PROTAC 3 bụ VHL na-ewe ọrụ PROTAC nke na-ebute mmebi nke EGFR na EGFR mutants na DC50 nke 11.7 nM na 22.3 nM maka HCC827 cell (Exon 19 del) na H3258R cell.
Ebumnuche: EGFR
