JBJ-04-125-02 R-isomer
Nkọwa ngwaahịa
Mkpado ngwaahịa
| Nha ngwugwu | Nnweta | Ọnụ ego (USD) |
Aha kemịkalụ:
(R) -2- (5-fluoro-2-hydroxyphenyl) -2- (1-oxo-6- (4- (piperazin-1-yl) phenyl) isoindolin-2-yl) - N- (thiazol-2). -yl) acetamide
Koodu Ọchịchọ:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
Koodu InChi:
InChi=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19 (15-23 (20)28 35)38)18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8,11,14-16,26,31,36H,9- 10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
Igodo InChi:
VHQVOTINPRYDAO-AREMUKBSSA-N
Okwu:
Solubility:
Nchekwa:
Nkọwa:
JBJ-04-125-02 bụ mutant-ahọrọ EGFR allosteric inhibitor nwere ọrụ mgbochi ọrịa kansa. Dị ka otu onye nnọchi anya, ọ nwere ike igbochi mmụba cell yana EGFRL858R/T790M/C797S na-egosi na vitro na in vivo. Nchikota osimertinib na JBJ-04-125-02 na-ebute mmụba nke apoptosis, mgbochi dị irè karị nke uto cellular, na mmụba na-arụ ọrụ na vitro na in vivo ma e jiri ya tụnyere ma ọ bụ otu onye ọrụ.
Ebumnuche: EGFR
