EAI-045

Aha kemịkalụ:

2- (5-fluoro-2-hydroxyphenyl) -2- (3-oxo-1H-isoindol-2-yl) - N- (1,3-thiazol-2-yl) acetamide

Koodu Ọchịchọ:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

Koodu InChi:

InChi=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8 -27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

Igodo InChi:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

Okwu:

EAI-045, EAI045, EAI 045, 1942114-09-1

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

Nkọwa:

EAI045 bụ ihe mgbochi EGFR dị ike ma họrọ. EAI045 lekwasịrị anya ahọrọ mutant EGFR na-eguzogide ọgwụ mana ọ na-echekwa ụdị nnabata anụ ọhịa. EAI045 na-egbochi L858R/T790M-mutant EGFR nwere ike dị obere na nyocha biochemical.

Ebumnuche: EGFR