AZD-3409

Aha kemịkalụ:

(S) -isopropyl 2- (2- (4-fluorophenethyl) -5- (((2S,4S) -4- (nicotinoylthio) pyrrolidin-2-yl) methyl) amino) benzamido) -4- (methylthio) butanoate

Koodu Ọchịchọ:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4=O)CCSC

Koodu InChi:

InChi=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30 -18-27(13-10-24(30)9-6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38) -28)45-34(42)25-5-4-15-36-19-25/h4-5,7-8,10-13,15,18-19,22,28-29, 31,37-38H,6,9,14,16-17,20-21H2,1-3H3,(H,39,40)/t28-,29-,31-/m0/s1

Igodo InChi:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Okwu:

AZD3409; AZD-3409; AZD 3409

Solubility: 

Nchekwa: 

Nkọwa:

AZD-3409 bụ ihe mgbochi prenyl transferase siri ike. AZD-3409 gosipụtara ike dị elu karịa lonafarnib. Ihe IC (50) pụtara maka cytotoxicity nke AZD3409 bụ 510 na mkpụrụ ndụ MEF, 10,600 na sel A549 na 6,170 na sel MCF7, n'otu n'otu. Na sel ndị a, IC (50) maka ọrụ FTase nke AZD3409 sitere na 3.0 ruo 14.2 nM na nke lonafarnib site na 0.26 ruo 31.3 nM. AZD3409 na-egbochi nkwụsịtụ dị elu karịa geranylgeranylation. Enweghị ike ijikọ ma mgbochi nke farnesylation na geranylgeranylation na ọrụ mgbochi nke ọgwụ ahụ. AZD3409 nwere ike na-arụ ọrụ na carcinoma ara na-eguzogide gefitinib.

Ebumnuche: prenyl transferase inhibitor