AZD-5069

Aha kemịkalụ:

N- (2- ((2,3-difluorobenzyl) thio)-6-((2R,3S) -3,4-dihydroxybutan-2-yl) oxy) pyrimidin-4-yl)zetidine-1-sulfonamide

Koodu Ọchịchọ:

O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O

Koodu InChi:

InChi=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16) 30-1 0-12-4-2-5-13 (19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2,1H3,(H ,21,22,23)/t11-,14+/m1/s1

Igodo InChi:

QZECRCLSIGFCIO-RISCZKNCSA-N

Okwu:

AZD-5069, AZD5069, AZD 5069, 878385-84-3

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

AZD-5069 bụ onye na-emegide CXCR2 dị ike ma họrọ nke nwere ikike igbochi ịkwaga neutrophil n'ime ikuku na ndị ọrịa nwere COPD. E gosiputara AZD-5069 ka ọ gbochie njikọ nke CXCL8 nke akpọrọ redio na CXCR2 mmadụ nwere uru pIC50 nke 9.1. Ọzọkwa, AZD5069 gbochiri neutrophil chemotaxis, na pA2 nke ihe dị ka 9.6, na okwu adhesion molecule, na pA2 nke 6.9, na nzaghachi CXCL1. AZD5069 bụ onye na-emegide CXCR2 ji nwayọọ nwayọọ na-agbanwe agbanwe nwere mmetụta nke oge na ọnọdụ okpomọkụ pụtara ìhè na nkà mmụta ọgwụ na njikọ nke kinetics. AZD-5069 nwekwara ike bara uru maka onye ọrịa na ọnọdụ mkpali.

Ebumnuche: CXCR2