EED226

Aha kemịkalụ:

N- (furan-2-ylmethyl) -8- (4- (methylsulfonyl) phenyl)-[1,2,4]triazolo [4,3-c] pyrimidin-5-amine

Koodu Ọchịchọ:

O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O

Koodu InChi:

InChi=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22) 18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)

Igodo InChi:

DYIRNMPIZZNBK-UHFFFAOYSA-N

Okwu:

EED226, EED-226, EED 226, 2083627-02-3

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

EED226 bụ onye na-egbochi EZH2 na EZH1 dị ike nke ukwuu, na-arụ ọrụ nke ọma ma na-ahọrọ nke a na-enyocha megide ọtụtụ ụdị epigenetic na ndị na-abụghị epigenetic. Ọ na-ebelata akara H3K27Me3 zuru ụwa ọnụ n'ime sel wee gosipụta nsonaazụ igbu mmadụ na sel na-ebu mmụgharị heterozygous Y641N. EED226 nwere permeability na-agafeghị oke dị ka atụpụtara na mkpụrụ ndụ Caco-2 na A → B = 3.0x10-6 cm / s, yana oke efflux na 7.6[1].

Ebumnuche: EED226