BS-181

Non Chimik:

N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pirimidin-5,7-diamine idroklorid

Kòd SMILES:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

Kòd InChi:

InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22() 19)28)24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15 ,23H2,1-2H3,(H,24,27);1H

InChi kle:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Mot:

Solibilite: 

Depo: 

Deskripsyon:

BS-181 se yon inibitè CDK trè selektif pou CDK7 ak yon IC (50) nan 21 nmol / L. Tès lòt CDK yo ansanm ak yon lòt 69 kinas te montre ke BS-181 sèlman inibit CDK2 nan konsantrasyon pi ba pase 1 mikromol / L, ak CDK2 yo te inibit 35-pli mwens pisan (IC (50) 880 nmol / L) pase CDK7. Nan selil MCF-7, BS-181 inibit fosforilasyon substrats CDK7, ankouraje arèstasyon sik selilè ak apoptoz pou anpeche kwasans liy selil kansè yo, epi li montre efè antitumoral nan vivo.

Sib: CDK7