Voruciclib

Non Chimik:

2-(2-Chloro-4-(trifluorometil)fenil)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-1-benzopyran -4-yonn

Kòd SMILES:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O) = CC (O) = C13

Kòd InChi:

InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(32-21) 1 9)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

InChi kle:

MRPGRAKIAJJGMM-OCCSQVGLSA-N

Mot:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Solibilite: 

Depo: 

Deskripsyon:

Voruciclib, ke yo rele tou P1446A-05, se yon inibitè pwoteyin kinaz espesifik pou kinaz 4 depandan siklin (CDK4) ak potansyèl aktivite antineoplastic. CDK4 inhibitor P1446A-05 espesyalman inibit CDK4-medyatè tranzisyon faz G1-S, arete bisiklèt selil ak anpeche kwasans selil kansè. Serine/threonine kinase CDK4 yo jwenn nan yon konplèks ak siklin G1 D-tip epi li se premye kinaz ki vin aktive sou eksitasyon mitogenik, lage selil ki soti nan yon etap trankil nan etap kwasans G1/S nan monte bisiklèt; Konplèks CDK-cyclin yo te montre fosforil retinoblastoma (Rb) faktè transcription nan kòmansman G1, deplase histon deacetylase (HDAC) ak bloke represyon transcriptional.

Sib: CDK4