THZ2
Pwodwi detay
Tags pwodwi
| Gwosè pake | Disponibilite | Pri (USD) |
| 100 mg | Nan Stock | 500 |
| 500 mg | Nan Stock | 800 |
| 1g | Nan Stock | 1200 |
| Plis gwosè | Jwenn Quotes | Jwenn Quotes |
Non Chimik:
N-[3-[[5-chloro-4-(1H-indol-3-yl)pirimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)but-2- enoyl] amino] benzamid
Kòd SMILES:
O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN) (C)C)=O)=C5
Kòd InChi:
InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23(17-22)37-31-34-19-26 (32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H, 35,40)(H,36,41)(H,34,37,38)/b14-7+
InChi kle:
FONRCZUZCHXWBD-VGOFMYFVSA-N
Mot:
THZ-2, THZ 2, THZ2, 1604810-84-5
Solibilite:Soluble nan DMSO
Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa).
Deskripsyon:
THZ2, yon analòg THZ1, ak potansyèl pou trete kansè nan tete Triple-negatif (TNBC), li se yon inibitè CDK7 ki pisan ak selektif ki genyen batay la enstabilite THZ1 nan vivo. IC50: CDK7 = 13.9 nM; Selil TNBC = 10 nM
Sib: CDK
