BI-847325

Inoa Kimia:

(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide

SMILES Code:

O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4

Code InChi:

InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2, 1-3H3,(H,30,34)(H,32,35)/b28-27-

Ki InChi:

FLBNLJLONKAPLR-DQSJHHFOSA-N

Hua'ōlelo:

BI-847325, BI847325, BI 847325, 1207293-36-4

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO BI-847325 he mea koho pālua MEK / Aurora kinase inhibitor me IC50 waiwai o 3, 25, 15, 25, a me 4 nM no X. laevis Aurora B, kanaka Aurora A a me Aurora C, a me kanaka MEK1 a me MEK2. Hiki iā ia ke keʻakeʻa i ka ulu a me ke ola ʻana o nā laina melanoma cell treatment-naive a me ka lāʻau lapaʻau, e hoʻemi ana i ka hōʻike ʻana o MEK a me Mcl-1 me ka hoʻonui ʻana i ka hōʻike o ka Bim protein pro-apoptotic. Ma ka 70 mg/kg, hoʻoulu ʻo BI-847325 i ka apoptosis i ka lāʻau lapaʻau-naive a me ka lāʻau lapaʻau xenografted melanoma i vivo.

Kuhikuhi: MEK/Aurora