BLU-667

BLU-667
  • inoa:BLU-667
  • Helu helu:CPD2049
  • Helu CAS.:2097132-94-8
  • Kaumaha Molekala:532.27
  • ʻO ke kumu hoʻohālike kimemika:C28H33FN8O2
  • No ka noiʻi ʻepekema wale nō, ʻaʻole no nā maʻi.

    Huahana Huahana

    Huahana Huahana

    Nui Puke Loaʻa Kumukuai (USD)

    Inoa Kimia:

    (1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pyrazol-1-yl)phenyl)ethyl)-1-methoxy-4-(4-methyl-6-( (5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide

    SMILES Code:

    CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

    Code InChi:

    InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27(38)32-19(3)20-5 -7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13-16,19,21H,9-12H2,1-4H3,(H,32, 38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

    Ki InChi:

    HUQPYQIGHTXBNW-BDHWGLMFSA-N

    Hua'ōlelo:

    BLU-667; BLU 667; BLU667

    Hiki ke hoʻoheheʻe:DMSO

    Waihona: 

    wehewehe:

    ʻO BLU-667 kahi mea hoʻopaneʻe ikaika a koho i nā mutations RET, fusions, a me nā mutants kūpaʻa i wānana ʻia. ʻO RET fusions nā mea hoʻokele nui o nā maʻi maʻi maʻi he nui, e like me ka maʻi kanesa a me ka maʻi thyroid, a ke hōʻike nei kā mākou noiʻi ʻana he kuleana nui ʻo RET i kekahi mau maʻi maʻi ʻaʻai a me ka umauma. Ma ka huli like ʻana i ka mea hoʻokele mua a wānana i nā mutants kūpaʻa e hoʻolilo i nā cell cancer insensitive i ka mālama ʻana me nā lāʻau lapaʻau i ʻae ʻia i kēia manawa,

    Pahuhopu: RET


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